Clinical Trials
Bipolar Disorder (Manic-Depressive Illness)
Featured Studies
Featured studies include only those currently recruiting participants. They are listed according to the date they were added to the ClinicalTrials.gov registry, with the most recent studies appearing first.
- Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder.
Interventional study. This study will evaluate whether lithium included as part of optimized medication treatment improves overall level of illness, symptoms of mania and depression, and quality of life in people with bipolar disorder. Ages 18-80. Locations in Stanford, CA; Boston, MA; Cleveland, OH; Philadelphia, PA; Pittsburgh, PA; San Antonio, TX.
- Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
- FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder.
Interventional study. This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder. Ages 18-60. Location in Indianapolis, IN.
- Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.
- Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder.
Interventional study. This study will evaluate the effectiveness of interpersonal and social rhythm therapy in treating adolescents with a bipolar spectrum disorder Ages 12-18. Location in Seattle, WA.
- Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder.
Evaluation study. This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness. Ages 18-75. Location in New Brunswick, NJ.
- Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
- Effectiveness of Family-Focused Treatment Plus Pharmacotherapy for Bipolar Disorder in Adolescents.
Interventional study. This study will evaluate the effectiveness of family-focused treatment (FFT) plus pharmacotherapy in treating adolescents with bipolar disorder. Ages 13-17. Locations in Boulder, CO; Cincinnati, OH; Pittsburgh, PA.
- Impact of Pregnancy and the Postpartum Period on Women With Bipolar Disorder.
Evaluation study. This study will determine the risk factors for a depressive, manic, or hypomanic episode during pregnancy and the postpartum period in women with bipolar disorder. Ages 18-45. Location in Boston, MA.
- Bipolar II Depression: Lithium, SSRI, or the Combination.
Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Cincinnati, OH; Dallas, TX.
- Treatment of Bipolar Mania in Older Adults.
Interventional study. This study will compare the benefits and side effects of lithium and divalproex in the treatment of older adults with bipolar mania. Ages 60 and over. Locations in Jackson, MS; Durham, NC; White Plains, NY; Cleveland, OH; Toronto, ON; Philadelphia, PA; Pittsburgh, PA; Houston, TX.
- Maintenance Treatment of Bipolar Depression.
Interventional study. This study will compare two different antidepressant treatment regimens to determine which is more effective in reducing symptoms of bipolar depression. Ages 18 and over. Location in San Antonio, TX.
- Reproductive Function and Mood in Women With Bipolar Disorder.
Evaluation study. This study will determine the effect of medication for bipolar disorder on the reproductive function and whether mood changes occur during the menstrual cycle in women with bipolar disorder. Ages 18-40. Location in Stanford, CA.
- Treatment of Early Age Mania.
Interventional study. This study will evaluate the effectiveness of the medications, lithium (Eskalith®), valproate (Depakote®), and risperidone (Risperdal®) in treating children and adolescents with bipolar disorder or symptoms of mania. Ages 6-15. Locations in Washington, DC; Baltimore, MD; St. Louis, MO; Pittsburgh, PA; Galveston, TX.
Search ClinicalTrials.gov for other NIH studies on Bipolar Disorder (Manic-Depressive Illness).
